A new case study published in Cureus by Saami Khalifian, MD; Alec D. McCarthy, MD; and Steven Yoelin, MD, examines the efficacy and safety of an injectable therapy for treating neck wrinkles and skin laxity. This therapy combines hyperdiluted calcium hydroxylapatite (CaHA), platelet-rich plasma (PRP), and hyaluronidase.
Two patients with moderate neck wrinkles and skin laxity received the treatment and were evaluated several months later.
The study found that a single treatment with the combined therapy improved skin texture and laxity.
The inclusion of PRP and hyaluronidase aimed to enhance the regenerative effects of CaHA. PRP is rich in growth factors that stimulate collagen production and regeneration, while hyaluronidase breaks down hyaluronic acid, promoting better diffusion and even product dispersion.
The findings from these cases provide preliminary evidence supporting the safety and efficacy of this innovative combination therapy for addressing neck wrinkles and laxity.
According to the researchers, this is the first documented instance of using CaHA in conjunction with hyaluronidase and PRP for skin priming.
Further investigations are needed to explore the application of this treatment for other anatomical regions and to clarify the role of each injected component.
Read complete findings at Cureus
More from The Blog
White Hats, Buckle Up: A Response to ELLE’s Med Spa Exposé
TL;DR: ELLE just ran a big investigation about counterfeit injectables, shady credentials, and limp oversight in med spas (published Aug 21, 2025). A lot of it is true (you know it, I know it)—and it’s exactly why ethical operators need to get loud, get transparent,...
Rhode Island Medical Spa Laws 2025: New Safety Act Requirements for Practice Owners
New legislation establishes mandatory facility licensing and enhanced supervision protocols for all Rhode Island medical spas - EFFECTIVE IMMEDIATELY! Rhode Island medical spa owners face significant regulatory changes following Governor Daniel McKee's signing of the...
The Medspa Owner’s Guide to Hiring and Training a Top-Tier Nurse Injector
How to bridge the skills gap and build your dream aesthetic team from the ground upEvery medspa owner knows the struggle: you're turning away clients because you can't find qualified nurse injectors. The aesthetic industry is exploding, but skilled injectors remain...
The Legal Facelift: How to Build, Run, and Transition a Compliant Med Spa – Part II
READ PART IAcross the country, the medical spa industry is booming – offering patients aesthetic treatments like injectables, microneedling, and laser hair removal in a relaxed, luxurious environment. But behind the beauty lies a heavily regulated business. Despite...
