What Happens to Botox and Fillers in Space?

Botox Meets Zero Gravity

On April 14, 2025, Katy Perry, alongside journalist Gayle King (who walked toward that rocket like it was the DMV on a Monday), and philanthropist (and Bezos fiance) Lauren Sánchez, embarked on a historic 11-minute suborbital flight aboard Blue Origin’s New Shepard rocket. This all-female crew, which also included former NASA engineer Aisha Bowe, civil rights activist Amanda Nguyen, and film producer Kerianne Flynn, experienced a few minutes of weightlessness as they crossed the Kármán line—the recognized boundary of space.​

While the mission was celebrated for its representation and inspiration, it also sparked lots of online chatter about the effects of space travel on cosmetic enhancements like Botox and dermal fillers. Given the crew’s visibly polished appearances, questions arose: How do these treatments hold up in the unique conditions of space?​

Botox and Fillers in Microgravity: What the Experts Say

In the microgravity environment of space, bodily fluids tend to shift towards the head, potentially causing facial puffiness. However, experts suggest that for short-duration flights like this one, the impact on cosmetic procedures is minimal.​

Dr. Giselle Prado-Wright, a cosmetic surgeon, explains that dermal fillers, particularly those made of hyaluronic acid, are designed to integrate seamlessly into natural tissue and are unlikely to be affected by brief periods of weightlessness.​

Similarly, Botox, which works by temporarily paralyzing specific muscles to reduce wrinkles, is injected directly into muscle tissue and is not expected to migrate or behave differently in space’s microgravity during short trips.​

Cosmetic Procedures Under Pressure

While space travel poses minimal risks to cosmetic enhancements during brief missions, other environments like scuba diving introduce different challenges. The pressure changes experienced during dives can potentially affect recent cosmetic procedures.​

According to the Divers Alert Network, it’s advisable to wait at least 3–7 days after Botox injections and 5–10 days after dermal filler treatments before engaging in scuba diving. This precaution helps ensure that the injected substances have settled properly and reduces the risk of complications such as migration or asymmetry.​

Staying Ahead in a Rapidly Evolving Landscape

As our world evolves—ushering in new experiences like space tourism and embracing wellness trends such as saunas, cold plunges, and biohacking—it’s crucial for aesthetic providers to remain informed about how these changes intersect with their practice. While brief exposures to microgravity or temperature extremes may have minimal impact on treatments like Botox and dermal fillers, the increasing popularity of activities that influence circulation and metabolism underscores the need for ongoing vigilance.​

In this dynamic landscape, providers must stay proactive, continually updating their knowledge to ensure patient safety and satisfaction. By understanding how emerging trends and lifestyle choices can affect aesthetic treatments, practitioners can better navigate the challenges and opportunities that arise, ensuring they remain at the forefront of their field.